2024 Refractoriness to treatment

Refractoriness to treatment

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WebOct 17, 2024 · The absence of a uniform and clinically relevant definition of severe postpartum haemorrhage hampers comparative studies and optimization of clinical management. The concept of persistent postpartum haemorrhage, based on refractoriness to initial first-line treatment, was proposed as an alternative to common definitions that … WebNCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine.

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WebNov 20, 2024 · Refractoriness to a MM agent was defined as lack of objective response, progression while receiving therapy or within 60 days of the last dose as standardized by the International Myeloma Working... WebJul 29, 2007 · These findings indicate that, in our models, refractoriness to anti-VEGF treatment is determined by the ability of tumors to prime and recruit CD11b + Gr1 + cells. You have full access to this ... mary grace shuffle

Refractoriness - an overview ScienceDirect Topics

WebAug 7, 2024 · Also, as some of the medications used for the control of aggressive behaviour are only prescribed in adulthood, the refractory group was composed of adults exclusively. All those in the refractory group had received at different times high-dose monotherapy and polypharmacy therapies. WebJul 20, 2024 · The spontaneous tumour’s refractoriness to cGAMP is abolished by co-treatment with AKT 1/2 inhibitor (AKTi). Combined treatment with cGAMP and AKTi induces extensive tumour EC apoptosis,... WebPlatelet transfusion refractoriness is the repeated failure to achieve the desired level of blood platelets in a patient following a platelet transfusion. The cause of refractoriness may be either immune or non-immune. Among immune-related refractoriness, antibodies against HLA antigens are the primary cause. hurrah or hurray

$Refractoriness of STING therapy is relieved by AKT inhibitor$

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WebJan 17, 2024 · Ibrutinib-refractoriness is determined by progression on repeated evaluations so that an effective therapy is not abandoned. There are two forms of ibrutinib relapse: progressive CLL and histologic transformation. Ibrutinib should not be discontinued in a relapsing patient without a new treatment plan in place. Web1. Showing or characterized by obstinate resistance to authority or control: refractory children; refractory behavior. 2. Difficult to melt or work; resistant to heat: a refractory … hurrah nightclubWebJan 16, 2014 · Refractoriness to oral iron treatment was defined as a hemoglobin (Hb) increment of <1 g/dL after 4 to 6 weeks of therapy at a daily dose of at least 100 mg of … hurrah movies

"WebOct 3, 2016 · As can be seen in other psychiatric disorders, refractoriness to treatment is an important problem for patients with OCD. OCD is a chronic disorder like collagen tissue disorders, with symptoms tending to wax and wane but rarely remitting spontaneously through the course of the disorder. An important part of OCD patients respond to … " - Refractoriness to treatment

Refractoriness to treatment

Treatment of patients with multiple myeloma progressing on

WebApr 4, 2024 · However, because several molecular targeted agents, including sorafenib, are now available based on their proven treatment efficacy from several randomized trials , the concept of TACE refractoriness was proposed to prevent the deterioration of liver function or stage progression during repeated TACE sessions [15, 24–26]. WebJan 31, 2024 · The word “refractory” in general use means stubborn or intractable, and in medicine it is specifically applied to disease that does not respond to treatment. …

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WebSep 1, 2011 · Refractoriness can be mitigated by early diagnose of RA patients, tight monitoring using appropriate tools to measure disease activity, identification of patients … WebFeb 13, 2024 · Current treatment of ITP is not strictly regimented. 7 First-line therapy usually consists of steroids (high-dose dexamethasone or prednisone) or IV immunoglobulin (IVIG), or even a combination of both for certain patients. Second-line treatment primarily includes thrombopoietin receptor agonists (TPO-RAs) and rituximab, with splenectomy deferred …

WebApr 8, 2024 · Axonal damage in the C-fibers leading to evoked potentials/increased refractoriness translated to monotonic increase/decrease of all quantitative pain markers (Figure 4 and Figure 5). However, the N C marker (that counts the number of times the pain signal crosses the typical π thresh = 25 Hz threshold) behaves very differently for the ... WebFeb 26, 2024 · Citation 9 These detection methods, however, require at least 1–2 rounds of radioactive iodine (RAI) treatment to make the final diagnosis of RAIR. In patients with disease progression and non-tumoricidal RAI uptake, the diagnosis is delayed even longer. ... Citation 30 All candidates with RAI refractoriness were categorized into the RAIR ...

WebMar 20, 2024 · The treatment of multiple myeloma (MM) has changed dramatically in the past decade with the introduction of new drugs into therapeutic strategies, both in the frontline and in the relapse settings. WebNov 20, 2024 · Refractoriness to a MM agent was defined as lack of objective response, progression while receiving therapy or within 60 days of the last dose as standardized by …

WebThe study group set three objectives: (1) to clarify the concept of treatment resistance or refractoriness; (2) to suggest criteria for defining or rating the degree of treatment …

WebJul 17, 2024 · Accordingly, we propose that high levels of PAF in serum could be a potential predictor of refractoriness to antihistamine treatment in CSU patients. For severe patients with high UAS7 scores, increasing antihistamines with the addition of a PAF antagonist may help to achieve better control of CU earlier. Further studies are required to ... mary grace siracuseWebJul 20, 2015 · If refractoriness is suspected, clinical assessment and treatment of potential contributory non-immune factors is necessary. At this time, published guidelines recommend provision of fresh ABO-identical apheresis platelet products with assessment of 10 min to 1-h post-transfusion platelet increments (Hod & Schwartz, 2008; Nahirniak et al, … mary grace sansrival priceWeb1. Showing or characterized by obstinate resistance to authority or control: refractory children; refractory behavior. 2. Difficult to melt or work; resistant to heat: a refractory material such as silica. 3. Resistant to treatment: a … mary grace singaporeWebSep 27, 2024 · Refractoriness to treatment is a substantial clinical concern. Several pharmacologic and other somatic interventions have been tried with variable results. The first step after the diagnosis of tardive dystonia induced by antipsychotic medications or other drugs is to taper and then discontinue the causative drugs. Many times, a severe ... mary grace shangri laWebtient demonstrates initial refractoriness to conventional doses of medication, the dose should be titrated to the maximum tolerable within the recommended range and … hurrah pass roadWebMar 16, 2024 · Refractoriness to platelet transfusions. Avoiding platelet transfusions as much as possible is important in alloimmunized patients. Prophylactic transfusions are … hurrah online casinoWebMay 1, 2001 · Refractoriness to infused platelets becomes a major clinical problem for many patients with acute myeloid leukemia (AML). Inadequate post-transfusion platelet count increments can be due to a ... mary grace singer