Web18. máj 2024 · NNT-AS1 knockdown blocks the Wnt/β-catenin signaling pathway via the miR-142-5p/SOX4 axis To investigate whether the Wnt/β-catenin signaling was associated with the regulatory mechanism underlying NNT-AS1 during GC, the expression levels of the Wnt/β-catenin signaling pathway-associated proteins, β-catenin, c-Myc, Bcl-2 and E … WebIn contrast, physical interaction between SOX4 and plakoglobin was suggested to inhibit canonical WNT/β-catenin signaling (Lai et al., 2011). These findings altogether suggest that SOXC proteins may control canonical WNT/β-catenin signaling at multiple levels.

恶性黑素瘤中SOX4的表达及其对Wntβcatenin信号途径作用研究

Web1. júl 2014 · During embryogenesis, Sox4 regulates mesenchymal and neural progenitor survival, as well as lymphocyte and myeloid differentiation, and contributes to pancreas, bone, and heart development.... Web19. nov 2011 · Wnt signaling induces nuclear colocalization of SOX4 and plakoglobin. Subcellular localization of plakoglobin and SOX4 were examined by confocal microscopy. PC3M HASOX4 stable cell line was treated with 100 ng/ml human recombinant WNT3A or 20 μM leptomycin b (LMB), or both WNT3A+LMB for 24 hr. broad chain technology

SOX4 - Wikipedia

WebRecent studies indicated that SOX4 might contribute to the tumor progression by regulating multiple signaling pathways, such as the PI3K/Akt, Wnt and p53 pathway. 37–39 … Web6. jan 2024 · Wnt3a is a member of the Wnt family of proteins and is capable of inhibiting the degradation of β-catenin by the Axin/APC/GSK3/CK1 complex, thereby activating the Wnt/β-catenin signaling pathway. The TOP flash assay was used to detect the activity of Wnt/β-catenin signaling pathway. Web肺癌 SOX4 EMT Wnt/β-catenin TGF-P. ... (HMG)-box 4,SOX4)可通过转录与非转录作用调控多癌种EMT的发生与进展,但其在肺癌发生发展中的作用仍待深入研究。本文在前期工作的 … broad chalke history festival