Thiopental clearance
WebThe apparent volume of distribution of thiopental is 233 L. The elimination half-life is 11.5 h and the plasma clearance value is 150 mL/min. The elimination half life of phenobarbital is shorter (6.1 +1- 3.3 hours) in infants and children, due solely to greater hepatic clearance. Thus, recovery time after large or repeated doses may be more ... WebAfter IV bolus, the total plasma clearance (CL) (295 +/- 132 mL/min) and volume of distribution at steady state (Vss) (139 +/- 38.5 L) of R-thiopental were significantly greater …
Thiopental clearance
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WebNov 18, 2012 · For the whole group, the mean steady-state plasma thiopental sodium concentration was 21.5 ± 10.3 mg/L and the corresponding clearance value (CL ss) was 2.25 ± 0.93 ml/min/kg. For each patient, the plasma concentration-time curve was plotted over the full period of data collection, according to a one-compartment model with linear … WebDec 13, 2012 · There is no difference in thiopental clearance between obese and lean subjects when normalized to total body weight. Propofol. Propofol is a highly lipophilic hypnotic (octanol–water partition coefficient of 4,300) and is the most commonly used hypnotic in the bariatric population. Like thiopental, propofol’s kinetics are highly …
WebThiopental was administered to neurosurgical patients as a drug for cerebral protection for up to 9 days either by continuous infusion (seven subjects) or Variability of thiopental … WebNov 25, 2012 · Several studies have documented increases in metabolism over time with phenytoin, pentobarbital, thiopental, antipyrine and lorazepam. Increases in tirilazad clearance were also observed but attributed to concurrent phenytoin therapy. No changes in the pharmacokinetics of ICG were apparent following head injury.
WebClearance appears to vary widely and may be increased with duration of barbiturate administration . Barbiturate levels are poorly correlated with electrical activity ... High-dose barbiturates suppress metabolism and, although both use of pentobarbital and thiopental have been reported, there is insufficient information about comparative ... WebFeb 23, 2006 · Pharmacokinetics 2. a. Explain the concept of pharmacokinetic modelling of single and multiple compartment models and define: half-life, clearance, volume of distribution, bioavailability, area under the “plasma concentration-time curve”, extraction ratio. The time taken for the plasma concentration of a drug to fall by 50% when first-order …
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WebThiopental has a LARGE Vd overall, and prolonged elimination half time in OBESE pts. Also prolonged in PREGNANCY r/t high protein binding. On the other hand, PEDIATRICS elimination half time is SHORTER due to more rapid hepatic clearance, meaning recovery is … folding round oak dining tableWebFEES CALCULATION Scheduled Fees Fees Calculation Building Assessment (A) Length X Breadth X Height X Prevailing Rate for All Applications + Fencing Fees @ N10,000 for the … egyptian cotton blankets queenWebSep 20, 2013 · Clearance of propofol is extremely high (greater than hepatic blood flow), suggesting additional extrahepatic, metabolism. Table 1. ... Thiopental is the most … egyptian cotton by duluxWeb7.4 Thiopental 7.5 Halothane 7.6 Pancuronium 7.7 Other Drugs Used in the Surgical Setting 7.8 Drug/Laboratory Test Interactions 8 USE IN SPECIFIC POPULATIONS . 8.1 Pregnancy 8.2 Lactation 8.4 Pediatric Use 8.5 Geriatric Use. 9 DRUG ABUSE AND DEPENDENCE 9.1 Controlled Substance. 9.2 Abuse 9.3 Dependence. 10 OVERDOSAGE 11 DESCRIPTION egyptian cotton blanketsWebMethohexital. Methohexital or methohexitone (marketed under the brand names Brevital and Brietal) is a drug which is a barbiturate derivative. It is classified as short-acting, and has a rapid onset of action. [2] It is similar in its effects to sodium thiopental, a drug with which it competed in the market for anaesthetics . egyptian cotton bed sheets singaporeWebDrug dosing is generally based on the volume of distribution for the loading dose and on the clearance for maintenance. In the obese patient, the volume of distribution is increased if the drug is distributed both in lean and fat tissues whereas the anesthetic drug clearance is usually normal or increased. ... Thiopental / pharmacokinetics ... egyptian cotton blankets kingWebThe terminal half-life was 6.99 ± 2.18 hours and body clearance was 1.51 ± 0.60 ml/kg x min. The degree of ionisation of thiopental in the pH of plasma is about 39%. Redistribution was found to be responsible for recovery from thiopental anaesthesia. 12. The mechanisms of thiopental metabolism were studied in a monkey injected with 35 mg/kg bw egyptian cotton blanket queen